Biological Role and Therapeutic Potential of IDH Mutations in Cancer.

Waitkus, Matthew S; Diplas, Bill H; Yan, Hai

Waitkus, Matthew S; Diplas, Bill H; Yan, Hai.

Afiliação

Waitkus MS; Department of Pathology, Duke University, Durham, NC, USA; The Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC, USA.
Diplas BH; Department of Pathology, Duke University, Durham, NC, USA; The Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC, USA.
Yan H; Department of Pathology, Duke University, Durham, NC, USA; The Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC, USA. Electronic address: hai.yan@dm.duke.edu.

Cancer Cell ; 34(2): 186-195, 2018 08 13.

Article em En | MEDLINE | ID: mdl-29805076

Assuntos

Isocitrato Desidrogenase/genética; Mutação; Neoplasias/genética; Animais; Glioma/tratamento farmacológico; Humanos; Isocitrato Desidrogenase/antagonistas & inibidores; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética; Camundongos; Neoplasias/tratamento farmacológico; Serina-Treonina Quinases TOR/fisiologia

Palavras-chave

2-hydroxyglutarate; acute myeloid leukemia; cancer therapy; glioblastoma; glioma; isocitrate dehydrogenase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isocitrato Desidrogenase / Mutação / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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