Induced expression of cathelicidins in trout (Oncorhynchus mykiss) challenged with four different bacterial pathogens.
J Pept Sci
; 24(7): e3089, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29808604
ABSTRACT
Cathelicidins are an important family of antimicrobial peptide effectors of innate immunity in vertebrates. Two members of this group, CATH-1 and CATH-2, have been identified and characterized in teleosts (ray-finned fish). In this study, we investigated the expression of these genes in different tissues of rainbow trout challenged with 4 different inactivated pathogens. By using qPCR, we detected a strong induction of both cath-1 and cath-2 genes within 24 hours after intraperitoneal inoculation with Lactococcus garvieae, Yersinia ruckeri, Aeromonas salmonicida, or Flavobacterium psychrophilum cells. Up to 700-fold induction of cath-2 was observed in the spleen of animals challenged with Y. ruckeri. Moreover, we found differences in the intensity and timing of gene up-regulation in the analyzed tissues. The overall results highlight the importance of cathelicidins in the immune response mechanisms of salmonids.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavobacterium
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Lactococcus
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Oncorhynchus mykiss
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Yersinia ruckeri
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Aeromonas salmonicida
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Catelicidinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article