Enhancing the therapeutic effect via elimination of hepatocellular carcinoma stem cells using Bmi1 siRNA delivered by cationic cisplatin nanocapsules.

Yang, Tan; Chen, Yuyuan; Zhao, Pengxuan; Xue, Huiying; You, Jia; Li, Bin; Liu, Yong; He, Chuanchuan; Zhang, Xiaojuan; Fan, Lingling; Lee, Robert J; Li, Lei; Ma, Xiang; Xu, Chuanrui; Xiang, Guangya

Yang, Tan; Chen, Yuyuan; Zhao, Pengxuan; Xue, Huiying; You, Jia; Li, Bin; Liu, Yong; He, Chuanchuan; Zhang, Xiaojuan; Fan, Lingling; Lee, Robert J; Li, Lei; Ma, Xiang; Xu, Chuanrui; Xiang, Guangya.

Afiliação

Yang T; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Chen Y; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Zhao P; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Xue H; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
You J; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Li B; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Liu Y; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
He C; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Zhang X; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Fan L; Stem Cell Center, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Lee RJ; Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Li L; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Ma X; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Xu C; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: xcr@hust.edu.cn.
Xiang G; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: gyxiang1968@hotmail.com.

Nanomedicine ; 14(7): 2009-2021, 2018 10.

Article em En | MEDLINE | ID: mdl-29842934

Assuntos

Carcinoma Hepatocelular/terapia; Cisplatino/administração & dosagem; Neoplasias Hepáticas/terapia; Nanocápsulas/administração & dosagem; Células-Tronco Neoplásicas/efeitos dos fármacos; Complexo Repressor Polycomb 1/antagonistas & inibidores; RNA Interferente Pequeno/genética; Animais; Antineoplásicos/administração & dosagem; Antineoplásicos/farmacologia; Apoptose; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patologia; Cátions; Ciclo Celular; Proliferação de Células; Cisplatino/farmacologia; Terapia Combinada; Resistencia a Medicamentos Antineoplásicos; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Nanocápsulas/química; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Complexo Repressor Polycomb 1/genética; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Bmi1 siRNA; Cancer stem cell; Co-delivery; Hepatocellular carcinoma; Nanocapsules

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Cisplatino / Carcinoma Hepatocelular / RNA Interferente Pequeno / Nanocápsulas / Complexo Repressor Polycomb 1 / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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