The ß2-adrenergic receptor is involved in differences in the protein degradation level of the pectoral muscle between fast- and slow-growing chicks during the neonatal period.
Gen Comp Endocrinol
; 267: 45-50, 2018 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-29857006
ABSTRACT
The aim of this study was to investigate whether ß2-AR mRNA expression is involved in either atrogin-1/MAFbx mRNA expression or protein degradation in chicken skeletal muscle by comparing fast- and slow-growing chicks during the neonatal period. Based on their body weight gain from 1 to 5â¯days of age, 5-day-old chicks (Gallus gallus domestics) were divided into a slow-growing and a fast-growing group, the mean weight gains of which were 6.3⯱â¯1.3â¯g/day and 11.3⯱â¯0.9â¯g/day, respectively. The ratio of pectoral muscle weight to total body weight was higher in the fast-growing group of chicks than in the slow-growing group. In addition, the plasma 3-methylhistidine concentration, an index of protein degradation in skeletal muscle, was significantly lower in the fast-growing than in the slow-growing chicks. The mRNA expression of ß2-AR, which we previously found is involved in decreasing muscle protein degradation by suppression atrogin-1/MAFbx mRNA expression, was significantly higher in the pectoral muscle of the fast-growing group compared with that of the slow-growing group. Concordantly, lower mRNA expression of atrogin-1/MAFbx was observed in the pectoral muscle of the fast-growing chicks. However, in the sartorius muscle, which is a muscle in the thigh, the ratio of the muscle weight to total body weight was not significantly different between the two groups of chicks at 5â¯days of age. In addition, there was no significant difference in the mRNA expressions of ß2-AR and atrogin-1/MAFbx in the sartorius muscle between these two groups. These results suggest that ß2-AR expression levels might be physiologically significant in the control of protein degradation in the pectoral muscle of neonatal chicks.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculos Peitorais
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Receptores Adrenérgicos beta 2
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Músculo Esquelético
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Proteínas Musculares
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article