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Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR.
Henry, Michael; Gallagher, Clair; Kelly, Ronan M; Frye, Christopher C; Osborne, Matthew D; Brady, Ciaran P; Barron, Niall; Clynes, Martin; Meleady, Paula.
Afiliação
  • Henry M; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Gallagher C; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Kelly RM; Eli Lilly and Company, LTC-North, 1200 Kentucky Avenue, Indianapolis, IN, 46225, United States.
  • Frye CC; Eli Lilly and Company, LTC-North, 1200 Kentucky Avenue, Indianapolis, IN, 46225, United States.
  • Osborne MD; Eli Lilly S.A. Irish Branch, Kinsale, Cork, Ireland.
  • Brady CP; Eli Lilly and Company, LTC-North, 1200 Kentucky Avenue, Indianapolis, IN, 46225, United States.
  • Barron N; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Clynes M; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
  • Meleady P; National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address: paula.meleady@dcu.ie.
J Biotechnol ; 281: 21-30, 2018 Sep 10.
Article em En | MEDLINE | ID: mdl-29860056
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Proteômica Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Proteômica Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article