Clinical data supporting a 2-dose schedule of MenB-FHbp, a bivalent meningococcal serogroup B vaccine, in adolescents and young adults.
Vaccine
; 36(28): 4004-4013, 2018 06 27.
Article
em En
| MEDLINE
| ID: mdl-29861182
ABSTRACT
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is a potentially devastating condition that can result in death and is associated with serious long-term sequelae in survivors. Vaccination is the preferred preventative strategy. Quadrivalent polysaccharide-based vaccines that protect against infection caused by meningococcal serogroups A, C, W, and Y are not effective against meningococcal serogroup B (MenB), which was responsible for approximately 60% and 35% of confirmed IMD cases in the European Union and the United States in 2016, respectively. A recombinant protein MenB vaccine (MenB-FHbp [bivalent rLP2086; Trumenba®]) has been approved for protection against MenB infection in persons 10-25â¯years of age in the United States and Canada and for individuals ≥10â¯years of age in the European Union and Australia. In these regions, MenB-FHbp is approved as a 2- or 3-dose primary vaccination schedule. This report will review the current evidence supporting administration of MenB-FHbp as a 2-dose primary vaccination schedule. Different contexts in which a 2- or 3-dose primary vaccination schedule might be preferred (eg, routine prospective vaccination vs outbreak control) are reviewed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
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Esquemas de Imunização
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Vacinas Meningocócicas
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Neisseria meningitidis Sorogrupo B
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Meningite Meningocócica
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Antígenos de Bactérias
Limite:
Adolescent
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Adult
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Humans
País/Região como assunto:
America do norte
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Oceania
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article