Synthesis of 2,3-Difunctionalized Benzofuran Derivatives through Palladium-Catalyzed Double Isocyanide Insertion Reaction.
Org Lett
; 20(12): 3500-3503, 2018 06 15.
Article
em En
| MEDLINE
| ID: mdl-29870267
ABSTRACT
A novel palladium-catalyzed tandem cyclization of 1-(allyloxy)-2-ethynylbenzene derivatives with isocyanides in the presence of water has been developed. The key intermediates, benzofuran-3-α-carbonyl aldehydes, were obtained through a simple acid hydrolysis process and could serve as precursors for structurally diverse 2,3-difunctionalized benzofuran derivatives such as important 2-benzofurylquinoxalines, benzofuran-3-α-ketoesters and benzofuryl ynediones. This transformation features convenient operation, simple and commercially available starting materials, broad functional-group compatibility, and moderate to good reaction yields.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article