Discovering mutated driver genes through a robust and sparse co-regularized matrix factorization framework with prior information from mRNA expression patterns and interaction network.

Xi, Jianing; Wang, Minghui; Li, Ao

Xi, Jianing; Wang, Minghui; Li, Ao.

Afiliação

Xi J; School of Information Science and Technology, University of Science and Technology of China, Huangshan Road, Hefei, 230027, China.
Wang M; School of Information Science and Technology, University of Science and Technology of China, Huangshan Road, Hefei, 230027, China. mhwang@ustc.edu.cn.
Li A; Centers for Biomedical Engineering, University of Science and Technology of China, Huangshan Road, Hefei, 230027, China. mhwang@ustc.edu.cn.

BMC Bioinformatics ; 19(1): 214, 2018 06 05.

Article em En | MEDLINE | ID: mdl-29871594

Assuntos

Redes Reguladoras de Genes; Genes Neoplásicos; Mutação; RNA Mensageiro/metabolismo; Algoritmos; Humanos

Palavras-chave

Bioinformatics; Cancer; Driver gene; Matrix factorization; Network regularization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Genes Neoplásicos / Redes Reguladoras de Genes / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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