HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120.

Keller, Paul W; Morrison, Orrianne; Vassell, Russell; Weiss, Carol D

Keller, Paul W; Morrison, Orrianne; Vassell, Russell; Weiss, Carol D.

Afiliação

Keller PW; Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Morrison O; Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Vassell R; Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Weiss CD; Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA carol.weiss@fda.hhs.gov.

J Virol ; 92(16)2018 08 15.

Article em En | MEDLINE | ID: mdl-29875245

Assuntos

Linfócitos T CD4-Positivos/metabolismo; Proteína gp120 do Envelope de HIV/metabolismo; Proteína gp41 do Envelope de HIV/metabolismo; HIV-1/fisiologia; Internalização do Vírus; Linhagem Celular; Proteína gp120 do Envelope de HIV/química; Proteína gp41 do Envelope de HIV/química; Proteína gp41 do Envelope de HIV/genética; HIV-1/genética; Humanos; Ligação Proteica; Conformação Proteica

Palavras-chave

HIV-1 entry; conformational changes; envelope glycoprotein; fusion; fusion inhibitor; gp120; gp41; resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Proteína gp41 do Envelope de HIV / Proteína gp120 do Envelope de HIV / HIV-1 / Internalização do Vírus Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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