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Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Woodhead, Jeffrey L; Paech, Franziska; Maurer, Martina; Engelhardt, Marc; Schmitt-Hoffmann, Anne H; Spickermann, Jochen; Messner, Simon; Wind, Mathias; Witschi, Anne-Therese; Krähenbühl, Stephan; Siler, Scott Q; Watkins, Paul B; Howell, Brett A.
Afiliação
  • Woodhead JL; DILIsym Services, Inc., a Simulations Plus company, Research Triangle Park, North Carolina, USA.
  • Paech F; University of Basel, Basel, Switzerland.
  • Maurer M; Basilea Pharmaceutica International Ltd., Basel, Switzerland.
  • Engelhardt M; Basilea Pharmaceutica International Ltd., Basel, Switzerland.
  • Schmitt-Hoffmann AH; Basilea Pharmaceutica International Ltd., Basel, Switzerland.
  • Spickermann J; Basilea Pharmaceutica International Ltd., Basel, Switzerland.
  • Messner S; InSphero, Inc., Basel, Switzerland.
  • Wind M; Basilea Pharmaceutica International Ltd., Basel, Switzerland.
  • Witschi AT; Basilea Pharmaceutica International Ltd., Basel, Switzerland.
  • Krähenbühl S; University of Basel, Basel, Switzerland.
  • Siler SQ; DILIsym Services, Inc., a Simulations Plus company, Research Triangle Park, North Carolina, USA.
  • Watkins PB; DILIsym Services, Inc., a Simulations Plus company, Research Triangle Park, North Carolina, USA.
  • Howell BA; DILIsym Services, Inc., a Simulations Plus company, Research Triangle Park, North Carolina, USA.
Clin Transl Sci ; 11(5): 498-505, 2018 09.
Article em En | MEDLINE | ID: mdl-29877622
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antibacterianos / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antibacterianos / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article