Resection of retroperitoneal sarcoma en-bloc with inferior vena cava: 20 year outcomes of a single institution.
J Surg Oncol
; 118(1): 127-137, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29878363
ABSTRACT
BACKGROUND:
Margin negative resection offers the best chance of long-term survival in retroperitoneal sarcoma (RPS). En-bloc resection of adjacent structures, including the inferior vena cava (IVC), is often required to achieve negative margins. We review our 20-year experience of en-bloc IVC and RPS resection.METHODS:
Retrospective review of patients with RPS resection involving the IVC were matched 13 by age and histology to RPS without IVC resection. Prognostic factors for overall survival (OS) and disease free survival (DFS) were assessed.RESULTS:
Thirty-two patients underwent RPS resection en-bloc with IVC. They were matched with 96 cases of RPS without IVC resection. Median OS of 59 months and DFS 18 months in IVC resection group was comparable to RPS resection without vascular involvement median OS 65 months, DFS 18 months (P = 0.519, P = 0.604). On multivariate analyses, R2 margin (OS HR = 6.52 [95%CI 1.18-36.09], P = 0.032) was associated with inferior OS. R2 margin and increased number of organs resected (DFS HR = 5.07, [1.15-22.27], P = 0.031, HR = 1.28 [1.01-1.62], P = 0.014) were associated with inferior DFS. Reconstructions included graft (n = 19, 59%), patch (n = 4, 13%), primary repair (n = 6, 19%), and ligation (n = 4, 13%).CONCLUSIONS:
RPS resection en-bloc with IVC can achieve equivalent rates of DFS and OS to patients without vascular involvement.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retroperitoneais
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Veia Cava Inferior
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Leiomiossarcoma
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Lipossarcoma
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article