Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4.

Vinogradova, Tatiana M; Sirenko, Syevda; Lukyanenko, Yevgeniya O; Yang, Dongmei; Tarasov, Kirill V; Lyashkov, Alexey E; Varghese, Nevin J; Li, Yue; Chakir, Khalid; Ziman, Bruce; Lakatta, Edward G

Vinogradova, Tatiana M; Sirenko, Syevda; Lukyanenko, Yevgeniya O; Yang, Dongmei; Tarasov, Kirill V; Lyashkov, Alexey E; Varghese, Nevin J; Li, Yue; Chakir, Khalid; Ziman, Bruce; Lakatta, Edward G.

Afiliação

Vinogradova TM; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD. vinogradovat@grc.nia.nih.gov.
Sirenko S; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Lukyanenko YO; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Yang D; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Tarasov KV; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Lyashkov AE; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Varghese NJ; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Li Y; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Chakir K; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Ziman B; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Lakatta EG; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.

Circ Arrhythm Electrophysiol ; 11(6): e005896, 2018 06.

Article em En | MEDLINE | ID: mdl-29880528

Assuntos

Potenciais de Ação; Relógios Biológicos; Nucleotídeo Cíclico Fosfodiesterase do Tipo 3/metabolismo; Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo; Frequência Cardíaca; Nó Sinoatrial/enzimologia; Potenciais de Ação/efeitos dos fármacos; Animais; Sinalização do Cálcio; AMP Cíclico/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Nucleotídeo Cíclico Fosfodiesterase do Tipo 3/genética; Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/genética; Ativação Enzimática; Frequência Cardíaca/efeitos dos fármacos; Cinética; Inibidores da Fosfodiesterase 3/farmacologia; Inibidores da Fosfodiesterase 4/farmacologia; Coelhos; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Nó Sinoatrial/citologia; Nó Sinoatrial/efeitos dos fármacos

Palavras-chave

calcium; calcium channel; phosphodiesterase; phospholamban; sarcoplasmic reticulum; sinoatrial node

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nó Sinoatrial / Relógios Biológicos / Potenciais de Ação / Nucleotídeo Cíclico Fosfodiesterase do Tipo 3 / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Frequência Cardíaca Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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