From underlying chemistry to therapeutic potential: open questions in the new field of lysine polyphosphorylation.
Curr Genet
; 65(1): 57-64, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-29881919
ABSTRACT
Polyphosphorylation is a newly described non-enzymatic post-translational modification wherein long chains of inorganic phosphates are attached to lysine residues. The first targets of polyphosphorylation identified were S. cerevisiae proteins Nsr1 and Top1. Building on this theme, we recently exploited functional genomics tools in yeast to identify 15 new targets, including a conserved network of nucleolar proteins implicated in ribosome biogenesis. We also described the polyphosphorylation of six human proteins, suggesting that this unique post-translational modification could be conserved throughout eukaryotes. The study of polyphosphorylation seems poised to uncover novel modes of protein regulation in pathways spanning diverse biological processes. In this review, we establish a framework for future work by outlining critical questions related to the biochemistry of polyphosphorylation, its therapeutic potential, and everything in between.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Proteínas Nucleares
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Transdução de Sinais
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Processamento de Proteína Pós-Traducional
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Proteínas de Ligação a RNA
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DNA Topoisomerases Tipo I
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Proteínas de Saccharomyces cerevisiae
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Lisina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article