Pleiotropic Effect of Lipoprotein-Apheresis on the Soluble Form of Activated Leukocyte Cell Adhesion Molecule (sALCAM) in Familial Hypercholesterolaemia.
Exp Clin Endocrinol Diabetes
; 127(5): 276-280, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-29890549
ABSTRACT
INTRODUCTION/BACKGROUND:
Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Remoção de Componentes Sanguíneos
/
Antígenos CD
/
Moléculas de Adesão Celular Neuronais
/
Lipoproteína(a)
/
Aterosclerose
/
Receptores de Reconhecimento de Padrão
/
Proteínas Fetais
/
Hipercolesterolemia
/
Inflamação
/
LDL-Colesterol
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article