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Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.
Colby, Donn J; Trautmann, Lydie; Pinyakorn, Suteeraporn; Leyre, Louise; Pagliuzza, Amélie; Kroon, Eugène; Rolland, Morgane; Takata, Hiroshi; Buranapraditkun, Supranee; Intasan, Jintana; Chomchey, Nitiya; Muir, Roshell; Haddad, Elias K; Tovanabutra, Sodsai; Ubolyam, Sasiwimol; Bolton, Diane L; Fullmer, Brandie A; Gorelick, Robert J; Fox, Lawrence; Crowell, Trevor A; Trichavaroj, Rapee; O'Connell, Robert; Chomont, Nicolas; Kim, Jerome H; Michael, Nelson L; Robb, Merlin L; Phanuphak, Nittaya; Ananworanich, Jintanat.
Afiliação
  • Colby DJ; SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Trautmann L; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Pinyakorn S; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Leyre L; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Pagliuzza A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Kroon E; Centre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
  • Rolland M; Centre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
  • Takata H; SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Buranapraditkun S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Intasan J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Chomchey N; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Muir R; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Haddad EK; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Tovanabutra S; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Ubolyam S; Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Bolton DL; Chulalongkorn Vaccine Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Fullmer BA; SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Gorelick RJ; SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Fox L; Department of Medicine, Division of Infectious Diseases & HIV Medicine at Drexel University College of Medicine, Philadelphia, PA, USA.
  • Crowell TA; Department of Medicine, Division of Infectious Diseases & HIV Medicine at Drexel University College of Medicine, Philadelphia, PA, USA.
  • Trichavaroj R; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • O'Connell R; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Chomont N; HIV-NAT, Thai Red Cross AIDS Research Center, Bangkok, Thailand.
  • Kim JH; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Michael NL; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Robb ML; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Phanuphak N; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Ananworanich J; Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.
Nat Med ; 24(7): 923-926, 2018 07.
Article em En | MEDLINE | ID: mdl-29892063
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Viral / Infecções por HIV / HIV-1 / Terapia Antirretroviral de Alta Atividade Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Viral / Infecções por HIV / HIV-1 / Terapia Antirretroviral de Alta Atividade Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article