Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution.
Chem Sci
; 9(19): 4505-4510, 2018 May 21.
Article
em En
| MEDLINE
| ID: mdl-29896393
ABSTRACT
A new class of tunable heterophosphole dimeric ligands have been designed and synthesized. These ligands have enabled the first examples of Cu-catalyzed hydrogenation of 2-substituted-1-tetralones and related heteroaryl ketones via dynamic kinetic resolution, simultaneously creating two contiguous stereogenic centers with up to >99 1 dr and 98 2 er. The ligand-Cu complexes were isolated and characterized by single crystal X-ray, and DFT calculations revealed a novel heteroligated dimeric copper hydride transition state.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article