Allelic and haplotype diversity of HLA-A, HLA-B and HLA-DRB1 gene at high resolution in the Nanning Han population.
Int J Immunogenet
; 45(4): 201-209, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29908012
ABSTRACT
The distribution of human leucocyte antigen (HLA) allele and haplotype varied among different ethnic populations. In this study, we investigated the allele and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 loci in the Nanning Han population who live in Guangxi province of China. We identified 26 HLA-A, 56 HLA-B and 31 HLA-DRB1 alleles in 562 Nanning individuals of Han ethnic group by sequence-based typing method. Of these, the three most common alleles in HLA-A, HLA-B and HLA-DRB1 loci, respectively, were A*1101 (32.12%), A*0207 (12.54%), A*2402 (12.01%); B*4601 (14.41%), B*1502 (13.61%), B*4001 (11.48%); DRB1*1501 (14.15%), DRB1*1602 (11.57%) and DRB1*1202 (10.14%). With the exception of HLA-DRB1, the p values of the HLA-A and HLA-B loci showed that the HLA allelic distribution in this population was in accordance with Hardy-Weinberg expectation (p > 0.05). A total of 173 HLA~A-B~DRB1 haplotype with a frequency of >0.1% were presented and the three most common haplotype were HLA-A*3303~B*5801~DRB1*0301 (6.12%), HLA-A*1101~B*1502~DRB1*1202 (3.39%) and HLA-A*1101~B*1502~DRB1*1501 (3.22%). The phylogenetic tree and the principal component analysis suggested that Nanning Han population had a relative close genetic relationship with Chinese Zhuang population and a relative distant genetic relationship with Northern Han Chinese. The information will be useful for anthropological studies, for HLA matching in transplantation and disease association studies in the Chinese population.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Haplótipos
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Antígenos HLA-A
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Antígenos HLA-B
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Povo Asiático
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Alelos
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Cadeias HLA-DRB1
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article