Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats.
Psychopharmacology (Berl)
; 235(8): 2447-2457, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29909425
ABSTRACT
RATIONALE The synthetic cathinone α-pyrrolidinopentiophenone (α-PVP) has been associated with bizarre public behavior in users. Association of such behavior with extended binges of drug use motivates additional investigation, particularly since a prior study found that half of male rats experience a binge of exceptionally high intake, followed by sustained lower levels of self-administration during the acquisition of intravenous self-administration (IVSA) of a related drug, 3,4-methylenedioxypyrovalerone. OBJECTIVES:
The binge-like acquisition pattern is novel for rat IVSA; thus, the present study sought to determine if this effect generalizes to IVSA of α-PVP in female rats.METHODS:
Female Wistar rats were trained in IVSA of α-PVP (0.05 mg/kg/inf) in experimental chambers containing an activity wheel. Groups were trained with the wheels fixed (No-Wheel group), fixed for the initial 5 days of acquisition or free to move throughout acquisition (Wheel group). The groups were next subjected to a wheel access switch and then all animals to dose-substitution (0.0125-0.3 mg/kg/inf) with the wheels alternately fixed and free to move.RESULTS:
Approximately half of the rats initiated their IVSA pattern with a binge day of exceptionally high levels of drug intake, independent of wheel access condition. Wheel activity was much lower in the No-Wheel group in the wheel switch post-acquisition. Dose-effect curves were similar for wheel access training groups, for binge/no binge phenotypic subgroups and were not altered with wheel access during the dose-substitution.CONCLUSION:
This confirms the high reinforcer effectiveness of α-PVP in female rats and the accompanying devaluation of wheel activity as a naturalistic reward.Palavras-chave
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Coleções:
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Base de dados:
MEDLINE
Assunto principal:
Pentanonas
/
Pirrolidinas
/
Recompensa
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Comportamento Aditivo
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Locomoção
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article