The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds.

Elwell-Cuddy, Trevor; Li, Miao; KuKanich, Butch; Lin, Zhoumeng

Elwell-Cuddy, Trevor; Li, Miao; KuKanich, Butch; Lin, Zhoumeng.

Afiliação

Elwell-Cuddy T; Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.
Li M; Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.
KuKanich B; Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.
Lin Z; Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.

J Vet Pharmacol Ther ; 41(5): 670-683, 2018 Oct.

Article em En | MEDLINE | ID: mdl-29923612

Assuntos

Analgésicos Opioides/farmacocinética; Metadona/farmacocinética; Analgésicos Opioides/análise; Animais; Cães/metabolismo; Cães/fisiologia; Feminino; Masculino; Metadona/análise; Modelos Biológicos; Manejo da Dor/métodos; Manejo da Dor/veterinária; Especificidade da Espécie; Distribuição Tecidual

Palavras-chave

Beagles; Greyhounds; methadone; opioids; physiologically based pharmacokinetic model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Analgésicos Opioides / Metadona Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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