A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice.

Varkhede, Ninad; Patel, Nita; Chang, William; Ruterbories, Kenneth; Forrest, M Laird

Varkhede, Ninad; Patel, Nita; Chang, William; Ruterbories, Kenneth; Forrest, M Laird.

Afiliação

Varkhede N; Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Ave, Lawrence, Kansas, 66047, USA.
Patel N; Drug Disposition, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana, 46285, USA.
Chang W; Lilly Biotechnology, Eli Lilly and Company, San Diego, California, 92121, USA.
Ruterbories K; Bioanalysis and Biotransformation, Research and Development, AbbVie, North Chicago, Illinois, USA.
Forrest ML; Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Ave, Lawrence, Kansas, 66047, USA. lforrest@ku.edu.

Pharm Res ; 35(8): 162, 2018 06 21.

Article em En | MEDLINE | ID: mdl-29931580

Assuntos

Adjuvantes Anestésicos/farmacocinética; Inflamação/metabolismo; Midazolam/farmacocinética; Adjuvantes Anestésicos/metabolismo; Animais; Citocromo P-450 CYP3A/metabolismo; Glucose-6-Fosfato Isomerase/metabolismo; Humanos; Masculino; Camundongos; Microssomos Hepáticos/metabolismo; Midazolam/metabolismo; Modelos Biológicos

Palavras-chave

cytokines; drug metabolism; glucose-6-phosphate isomerase; inflammation; physiologically based pharmacokinetic model

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Midazolam / Inflamação / Adjuvantes Anestésicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google