Neuroprotective effects of INT-777 against Aß<sub>1-42</sub>-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice.

Wu, Xian; Lv, Yang-Ge; Du, Yi-Feng; Chen, Fang; Reed, Miranda N; Hu, Mei; Suppiramaniam, Vishnu; Tang, Su-Su; Hong, Hao

Neuroprotective effects of INT-777 against Aß_1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice.

Wu, Xian; Lv, Yang-Ge; Du, Yi-Feng; Chen, Fang; Reed, Miranda N; Hu, Mei; Suppiramaniam, Vishnu; Tang, Su-Su; Hong, Hao.

Afiliação

Wu X; Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China.
Lv YG; Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China.
Du YF; Department of Drug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL, USA.
Chen F; Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China.
Reed MN; Department of Drug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL, USA.
Hu M; Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China.
Suppiramaniam V; Department of Drug Discovery and Development, School of Pharmacy, Auburn University, Auburn, AL, USA.
Tang SS; Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China. Electronic address: tang_susu@126.com.
Hong H; Department of Pharmacology, Key Laboratory of Neuropsychiatric Diseases, China Pharmaceutical University, Nanjing 210009, China. Electronic address: honghao@cpu.edu.cn.

Brain Behav Immun ; 73: 533-545, 2018 10.

Article em En | MEDLINE | ID: mdl-29935310

Assuntos

Ácidos Cólicos/farmacologia; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/efeitos adversos; Peptídeos beta-Amiloides/metabolismo; Animais; Apoptose/efeitos dos fármacos; Encéfalo/metabolismo; Caspase 3/metabolismo; Ácidos Cólicos/metabolismo; Disfunção Cognitiva/tratamento farmacológico; Modelos Animais de Doenças; Hipocampo/metabolismo; Masculino; Aprendizagem em Labirinto/efeitos dos fármacos; Memória/efeitos dos fármacos; Transtornos da Memória/metabolismo; Camundongos; Camundongos Endogâmicos ICR; Neuroimunomodulação/efeitos dos fármacos; Neurônios/metabolismo; Fármacos Neuroprotetores/metabolismo; Fármacos Neuroprotetores/farmacologia; Fragmentos de Peptídeos/efeitos adversos; Fragmentos de Peptídeos/metabolismo

Palavras-chave

Alzheimer's disease; Apoptosis; Aß(142); Cognitive; INT-777; Memory; Neuroinflammation; Neurotoxicity; Synaptic dysfunction; TGR5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Cólicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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