Systematic review of prostaglandin analogues for retained placenta.
Int J Gynaecol Obstet
; 143(1): 19-23, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29939397
ABSTRACT
BACKGROUND:
Medical management of retained placenta could be a safe alternative to manual removal.OBJECTIVE:
To evaluate the efficacy of prostaglandin analogues for retained placenta. SEARCH STRATEGY MEDLINE, EMBASE, CENTRAL, ICTRP, LILACS, and OpenSIGLE were searched without language restrictions from inception to January 31, 2017, by combining terms for retained placenta and prostaglandin analogues. SELECTION CRITERIA Randomized controlled trials comparing prostaglandin analogues with any other intervention. DATA COLLECTION ANDANALYSIS:
Trials were independently assessed for inclusion, data extraction, and risk of bias. Data were extracted for meta-analyses. GRADE was used to evaluate the quality of data. MAINRESULTS:
Seven randomized controlled trials (851 patients) were included. Prostaglandins did not increase the placenta expulsion rate (relative risk [RR] 1.40, 95% confidence interval [CI] 0.83-2.36) or decrease maternal transfusion (RR 0.72, 95% CI 0.43-1.22). In comparison with oxytocin, prostaglandins did not modify the expulsion rate (RR 1.26, 95% CI 0.90-1.78), maternal transfusion (RR 1.05, 95% CI 0.27-4.09), or time for delivery of placenta (mean difference -1.56 minutes, 95% CI, -9.25-6.13). Three trials comparing prostaglandins with oxytocin agonists, ergometrine, and manual removal reported similar results.CONCLUSIONS:
Prostaglandin analogues do not offer an effective alternative for management of retained placenta.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ocitócicos
/
Prostaglandinas Sintéticas
/
Placenta Retida
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Systematic_reviews
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article