Human Metabolome Changes after a Single Dose of 3,4-Methylenedioxymethamphetamine (MDMA) with Special Focus on Steroid Metabolism and Inflammation Processes.

Boxler, Martina I; Streun, Gabriel L; Liechti, Matthias E; Schmid, Yasmin; Kraemer, Thomas; Steuer, Andrea E

Boxler, Martina I; Streun, Gabriel L; Liechti, Matthias E; Schmid, Yasmin; Kraemer, Thomas; Steuer, Andrea E.

Afiliação

Boxler MI; Department of Forensic Pharmacology & Toxicology, Zurich Institute of Forensic Medicine , University of Zurich , 8057 Zurich , Switzerland.
Streun GL; Department of Forensic Pharmacology & Toxicology, Zurich Institute of Forensic Medicine , University of Zurich , 8057 Zurich , Switzerland.
Liechti ME; Psychopharmacology Research, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research , University Hospital Basel, University of Basel , 4031 Basel , Switzerland.
Schmid Y; Psychopharmacology Research, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research , University Hospital Basel, University of Basel , 4031 Basel , Switzerland.
Kraemer T; Department of Forensic Pharmacology & Toxicology, Zurich Institute of Forensic Medicine , University of Zurich , 8057 Zurich , Switzerland.
Steuer AE; Department of Forensic Pharmacology & Toxicology, Zurich Institute of Forensic Medicine , University of Zurich , 8057 Zurich , Switzerland.

J Proteome Res ; 17(8): 2900-2907, 2018 08 03.

Article em En | MEDLINE | ID: mdl-29947220

Assuntos

Inflamação/induzido quimicamente; Metaboloma/efeitos dos fármacos; N-Metil-3,4-Metilenodioxianfetamina/farmacologia; Esteroides/metabolismo; Coleta de Amostras Sanguíneas; Calcitriol/metabolismo; Estudos Cross-Over; Humanos; Hidrocortisona/metabolismo; Mediadores da Inflamação/metabolismo; Espectrometria de Massas; Metabolômica/métodos; Pregnenolona/metabolismo; Fatores de Tempo

Palavras-chave

3,4-methylenedioxymethamphetamine (MDMA); calcitriol; ecstasy; inflammation; placebo-controlled; pregnenolone sulfate; untargeted metabolomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroides / N-Metil-3,4-Metilenodioxianfetamina / Metaboloma / Inflamação Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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