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Differences in gene mutations according to gender among patients with colorectal cancer.
Tsai, Yi-Jian; Huang, Sheng-Chieh; Lin, Hung-Hsin; Lin, Chun-Chi; Lan, Yuan-Tzu; Wang, Huann-Sheng; Yang, Shung-Haur; Jiang, Jeng-Kai; Chen, Wei-Shone; Lin, Tzu-Chen; Lin, Jen-Kou; Chang, Shih-Ching.
Afiliação
  • Tsai YJ; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
  • Huang SC; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
  • Lin HH; Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Lin CC; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
  • Lan YT; Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Wang HS; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
  • Yang SH; Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Jiang JK; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
  • Chen WS; Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Lin TC; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
  • Lin JK; Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Chang SC; Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General Hospital, No 201,Sec 2, Shih-Pai Rd, 11217, Taipei, Taiwan.
World J Surg Oncol ; 16(1): 128, 2018 Jul 05.
Article em En | MEDLINE | ID: mdl-29976257
BACKGROUND: The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. METHODS: A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans' General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-ß, PIK3CA, PTEN, FBXW7, AKT1, and MSI. RESULTS: There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-ß (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. CONCLUSION: Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas B-raf / Mutação Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas B-raf / Mutação Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article