Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior.

Khan, Tarique; Kandola, Tejbir S; Wu, Jianzheng; Venkatesan, Shriram; Ketter, Ellen; Lange, Jeffrey J; Rodríguez Gama, Alejandro; Box, Andrew; Unruh, Jay R; Cook, Malcolm; Halfmann, Randal

Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior.

Khan, Tarique; Kandola, Tejbir S; Wu, Jianzheng; Venkatesan, Shriram; Ketter, Ellen; Lange, Jeffrey J; Rodríguez Gama, Alejandro; Box, Andrew; Unruh, Jay R; Cook, Malcolm; Halfmann, Randal.

Afiliação

Khan T; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Kandola TS; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Wu J; Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Venkatesan S; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Ketter E; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Lange JJ; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Rodríguez Gama A; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Box A; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Unruh JR; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Cook M; Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Halfmann R; Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address: rhn@stowers.org.

Mol Cell ; 71(1): 155-168.e7, 2018 07 05.

Article em En | MEDLINE | ID: mdl-29979963

Assuntos

Fatores de Terminação de Peptídeos/metabolismo; Proteínas Priônicas/metabolismo; Agregados Proteicos; Proteínas de Saccharomyces cerevisiae/metabolismo; Saccharomyces cerevisiae/metabolismo; Citometria de Fluxo; Fatores de Terminação de Peptídeos/genética; Proteínas Priônicas/genética; Saccharomyces cerevisiae/citologia; Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/genética

Palavras-chave

DAmFRET; amyloid; low-complexity sequences; nucleation barrier; phase transition; photoswitchable; prions; protein aggregation; proteotoxicity; supersaturation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Fatores de Terminação de Peptídeos / Proteínas de Saccharomyces cerevisiae / Agregados Proteicos / Proteínas Priônicas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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