Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient.

Horio, Yuko; Takamatsu, Koutaro; Tamanoi, Daisuke; Sato, Ryo; Saruwatari, Koichi; Ikeda, Tokunori; Nakane, Shunya; Nakajima, Makoto; Saeki, Sho; Ichiyasu, Hidenori; Fujii, Kazuhiko; Tomita, Yusuke

Horio, Yuko; Takamatsu, Koutaro; Tamanoi, Daisuke; Sato, Ryo; Saruwatari, Koichi; Ikeda, Tokunori; Nakane, Shunya; Nakajima, Makoto; Saeki, Sho; Ichiyasu, Hidenori; Fujii, Kazuhiko; Tomita, Yusuke.

Afiliação

Horio Y; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Takamatsu K; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tamanoi D; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Sato R; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Saruwatari K; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Ikeda T; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Nakane S; Department of clinical investigation (biostatistics), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Nakajima M; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Saeki S; Asian Neurological Intractable Diseases Research and Clinic (AIDReC), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Ichiyasu H; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Fujii K; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tomita Y; Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Eur J Immunol ; 48(10): 1764-1767, 2018 10.

Article em En | MEDLINE | ID: mdl-29981156

ABSTRACT

ABSTRACT

PD-1 blockade therapy activates T cells by blocking the interaction between PD-1 and PD-L1 and promotes IFN-Î³ and Th1 cytokine production. In turn, IFN-Î³ and Th1 cytokines produced by activated T cells promote TF synthesis in monocytes/macrophages, which results in hypercoagulability leading to thrombosis.

Assuntos

Anticorpos Monoclonais Humanizados/efeitos adversos; Transtornos da Coagulação Sanguínea/induzido quimicamente; Carcinoma Pulmonar de Células não Pequenas/complicações; Carcinoma Pulmonar de Células não Pequenas/terapia; Anticorpos Monoclonais Humanizados/uso terapêutico; Antineoplásicos Imunológicos/efeitos adversos; Antineoplásicos Imunológicos/uso terapêutico; Encéfalo/diagnóstico por imagem; Encéfalo/patologia; Infarto Cerebral/induzido quimicamente; Citocinas/imunologia; Genes cdc; Humanos; Ativação Linfocitária; Imageamento por Ressonância Magnética; Masculino; Pessoa de Meia-Idade; Metástase Neoplásica; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Trombose/diagnóstico; Trombose/etiologia

Palavras-chave

Immune checkpoint blockade; Immune-related adverse event; Lung cancer; Tissue factor; Trousseau's syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos da Coagulação Sanguínea / Carcinoma Pulmonar de Células não Pequenas / Anticorpos Monoclonais Humanizados Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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