E. coli strain engineering for the production of advanced biopharmaceutical products.
FEMS Microbiol Lett
; 365(15)2018 08 01.
Article
em En
| MEDLINE
| ID: mdl-29982628
ABSTRACT
Since the emergence of the biopharmaceutical industry in the 1980's, Escherichia coli, has played an important role in the industrial production of recombinant proteins and plasmid DNA for therapeutic use. Currently, advanced biopharmaceutical products, including rationally designed recombinant proteins and viral-vector gene therapies, offer unprecedented promise for the long-term management, and even cure of disease. As such, E. coli remains an important production host for the biopharmaceutical industry. This review provides insight into the industrially relevant strain engineering approaches used to enhance both the quantity and quality of these therapeutic products.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes
/
Escherichia coli
/
Engenharia Metabólica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article