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Significance and outcome of living-donor liver transplantation in acute mushroom intoxication.
Baskiran, A; Dirican, A; Ozgor, D; Kement, M; Koc, S; Sahin, T T; Ates, M; Yilmaz, S.
Afiliação
  • Baskiran A; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Dirican A; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Ozgor D; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Kement M; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Koc S; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Sahin TT; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Ates M; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
  • Yilmaz S; Department of General Surgery, Inonu University Turgut Ozal Medical Center, Faculty of Medicine, Institute of Liver Transplantation, Malatya, Turkey.
Niger J Clin Pract ; 21(7): 888-893, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29984721
INTRODUCTION: Mushroom intoxication (MT) can lead to acute liver injury which may result in Mushroom intoxication-related liver failure (M-ALF) requiring liver transplantation (LT). In the present study, we want to share the experience of our institute regarding living-donor LT (LDLT) due to mushroom poisoning. AIM: The aim of this study is to identify the predictors of poor prognosis in patients with ALF secondary to mushroom intoxication requiring LDLT. MATERIALS AND METHODS: All patients with MT between 2008 and 2016 were evaluated. Demographics, symptoms, interval between symptoms and admission to our institute, laboratory data, model for end-stage liver disease (MELD)/pediatric end-stage liver disease (PELD) scores, clinical course, and outcomes of supportive therapy and LT were evaluated. There were two groups in the study: Group A = responsive to supportive therapy (n = 9) versus Group B = unresponsive to supportive therapy (n = 9). RESULTS: During the study, a total of 18 patients were admitted with M-ALF. Twelve (66.7%) of them were female, and the mean age was 39.9 ± 18.2 years. All of the nine patients in Group A fully recovered with supportive therapy. In Group B, one patient died during waiting period for LT and 8 patients received LDLT LDLT. Three of the eight patients who were transplanted died in the postoperative early period within postoperative 5 days. The patients in Group B had significantly higher MELD/PELD scores and encephalopathy rate than in Group A (P < 0.05). International normalized ratio (INR), bilirubin, ammonium levels, and platelet count were significantly different between groups (P < 0.05). The patients in Group B had significantly longer interval before admission to our institute (P < 0.05). CONCLUSION: The presence of encephalopathy, higher MELD/PELD, INR, bilirubin, ammonium levels, and lower platelet count was related to poor prognosis in MT. LDLT provides a good therapeutic option in patients with M-ALF. The time is a crucial factor in successful treatment of MT. Early admission to a tertiary referral center with expertise in LT results in a better prognosis and increased survival following M-ALF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Intoxicação Alimentar por Cogumelos / Transplante de Fígado / Falência Hepática Aguda / Doadores Vivos Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Intoxicação Alimentar por Cogumelos / Transplante de Fígado / Falência Hepática Aguda / Doadores Vivos Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2018 Tipo de documento: Article