The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase, is a major determinant of Ca<sup>2+</sup> alternans in intact mouse hearts.

Sun, Bo; Wei, Jinhong; Zhong, Xiaowei; Guo, Wenting; Yao, Jinjing; Wang, Ruiwu; Vallmitjana, Alexander; Benitez, Raul; Hove-Madsen, Leif; Chen, S R Wayne

The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca²⁺-ATPase, is a major determinant of Ca²⁺ alternans in intact mouse hearts.

Sun, Bo; Wei, Jinhong; Zhong, Xiaowei; Guo, Wenting; Yao, Jinjing; Wang, Ruiwu; Vallmitjana, Alexander; Benitez, Raul; Hove-Madsen, Leif; Chen, S R Wayne.

Afiliação

Sun B; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Wei J; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Zhong X; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Guo W; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Yao J; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Wang R; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Vallmitjana A; the Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08034, Spain, and.
Benitez R; the Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08034, Spain, and.
Hove-Madsen L; the Biomedical Research Institute of Barcelona (IIBB), CSIC, Sant Pau, Hospital de Sant Pau, Barcelona 08025, Spain.
Chen SRW; From the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada, swchen@ucalgary.ca.

J Biol Chem ; 293(35): 13650-13661, 2018 08 31.

Article em En | MEDLINE | ID: mdl-29986885

Assuntos

Cálcio/metabolismo; Miocárdio/metabolismo; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo; Animais; Sinalização do Cálcio; Proteínas de Ligação ao Cálcio/genética; Proteínas de Ligação ao Cálcio/metabolismo; Camundongos; Camundongos Knockout; Mutação Puntual; Canal de Liberação de Cálcio do Receptor de Rianodina/genética

Palavras-chave

Ca2+ alternans; Ca2+ release refractoriness; calcium; calcium ATPase; calcium imaging; calcium intracellular release; cardiac dysfunction; confocal Ca2+ imaging; endoplasmic reticulum (ER); intact heart imaging; phospholamban; ryanodine receptor; sarcoplasmic reticulum (SR); ventricular tachyarrhythmia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cálcio / Canal de Liberação de Cálcio do Receptor de Rianodina / ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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