Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence.

Ke, Ruian; Li, Hui; Wang, Shuyi; Ding, Wenge; Ribeiro, Ruy M; Giorgi, Elena E; Bhattacharya, Tanmoy; Barnard, Richard J O; Hahn, Beatrice H; Shaw, George M; Perelson, Alan S

Ke, Ruian; Li, Hui; Wang, Shuyi; Ding, Wenge; Ribeiro, Ruy M; Giorgi, Elena E; Bhattacharya, Tanmoy; Barnard, Richard J O; Hahn, Beatrice H; Shaw, George M; Perelson, Alan S.

Afiliação

Ke R; Department of Mathematics, North Carolina State University, Raleigh, NC 27695.
Li H; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Wang S; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ding W; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.
Ribeiro RM; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Giorgi EE; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.
Bhattacharya T; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Barnard RJO; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.
Hahn BH; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Shaw GM; Laboratory of Biomathematics, Faculty of Medicine, University of Lisbon, 1600-276 Lisbon, Portugal.
Perelson AS; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.

Proc Natl Acad Sci U S A ; 115(30): E7139-E7148, 2018 07 24.

Article em En | MEDLINE | ID: mdl-29987026

Assuntos

Adaptação Fisiológica; Antivirais/uso terapêutico; Farmacorresistência Viral; Hepacivirus; Hepatite C; Modelos Biológicos; Adaptação Fisiológica/efeitos dos fármacos; Adaptação Fisiológica/genética; Farmacorresistência Viral/efeitos dos fármacos; Farmacorresistência Viral/genética; Hepacivirus/genética; Hepacivirus/metabolismo; Hepatite C/tratamento farmacológico; Hepatite C/genética; Hepatite C/metabolismo; Humanos

Palavras-chave

hepatitis C virus; mathematical modeling; phylodynamic modeling; virus evolution; virus persistence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Adaptação Fisiológica / Hepatite C / Hepacivirus / Farmacorresistência Viral / Modelos Biológicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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