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Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.
Karhu, S Tuuli; Välimäki, Mika J; Jumppanen, Mikael; Kinnunen, Sini M; Pohjolainen, Lotta; Leigh, Robert S; Auno, Samuli; Földes, Gábor; Boije Af Gennäs, Gustav; Yli-Kauhaluoma, Jari; Ruskoaho, Heikki; Talman, Virpi.
Afiliação
  • Karhu ST; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Välimäki MJ; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Jumppanen M; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland.
  • Kinnunen SM; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Pohjolainen L; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Leigh RS; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland.
  • Auno S; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Földes G; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Boije Af Gennäs G; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
  • Yli-Kauhaluoma J; National Heart and Lung Institute, Imperial College London, London, UK.
  • Ruskoaho H; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Talman V; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
Arch Toxicol ; 92(9): 2897-2911, 2018 09.
Article em En | MEDLINE | ID: mdl-29987409
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Toxicidade / Fator de Transcrição GATA4 / Bibliotecas de Moléculas Pequenas / Células-Tronco Pluripotentes Induzidas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Toxicidade / Fator de Transcrição GATA4 / Bibliotecas de Moléculas Pequenas / Células-Tronco Pluripotentes Induzidas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article