Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation.

Zhang, Hailong; Chen, Xi; Zong, Beibei; Yuan, Hongmin; Wang, Zhizeng; Wei, Yinxiang; Wang, Xuance; Liu, Guangchao; Zhang, Jun; Li, Shulian; Cheng, Guanchang; Wang, Yaohui; Ma, Yuanfang

Zhang, Hailong; Chen, Xi; Zong, Beibei; Yuan, Hongmin; Wang, Zhizeng; Wei, Yinxiang; Wang, Xuance; Liu, Guangchao; Zhang, Jun; Li, Shulian; Cheng, Guanchang; Wang, Yaohui; Ma, Yuanfang.

Afiliação

Zhang H; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Chen X; Department of General Pathology, Huaihe Hospital, Henan University, Kaifeng, China.
Zong B; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Yuan H; Department of Thyroid Breast Surgery, Huaihe Hospital, Henan University, Kaifeng, China.
Wang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Wei Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Wang X; Centre for Translational Medicine, Huaihe Hospital, Henan University, Kaifeng, China.
Liu G; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Zhang J; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Li S; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Cheng G; Department of Cardiac Surgery, Huaihe Hospital, Henan University, Kaifeng, China.
Wang Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.
Ma Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medicine, Henan University, Kaifeng, China.

J Cell Mol Med ; 22(9): 4437-4448, 2018 09.

Article em En | MEDLINE | ID: mdl-29993180

Assuntos

Antioxidantes/farmacologia; Cardiotônicos/farmacologia; Diabetes Mellitus Experimental/tratamento farmacológico; Cardiomiopatias Diabéticas/tratamento farmacológico; Inflamassomos/efeitos dos fármacos; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Animais; Antioxidantes/isolamento & purificação; Glicemia/efeitos dos fármacos; Glicemia/metabolismo; Cardiotônicos/isolamento & purificação; Proteínas de Transporte/genética; Proteínas de Transporte/metabolismo; Linhagem Celular; Citocromos c/genética; Citocromos c/metabolismo; Diabetes Mellitus Experimental/induzido quimicamente; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/patologia; Cardiomiopatias Diabéticas/induzido quimicamente; Cardiomiopatias Diabéticas/genética; Cardiomiopatias Diabéticas/patologia; Regulação da Expressão Gênica; Gynostemma/química; Inflamassomos/metabolismo; Interleucina-18/genética; Interleucina-18/metabolismo; Interleucina-1beta/genética; Interleucina-1beta/metabolismo; Masculino; Miócitos Cardíacos/citologia; Miócitos Cardíacos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/agonistas; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Estresse Oxidativo; Extratos Vegetais/isolamento & purificação; Extratos Vegetais/farmacologia; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/antagonistas & inibidores; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Estreptozocina

Palavras-chave

NLRP3 inflammasome; ROS; cytochrome c; diabetic cardiomyopathy; gypenosides; high glucose

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiotônicos / Diabetes Mellitus Experimental / Cardiomiopatias Diabéticas / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Antioxidantes Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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