Effect of forskolin on platelet deaggregation and cyclic AMP generation.
Naunyn Schmiedebergs Arch Pharmacol
; 331(1): 119-21, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-2999615
ABSTRACT
The diterpene, forskolin, induced a partial deaggregation of ADP- or collagen-aggregated human platelets in vitro. An increase in platelet cyclic AMP by forskolin was assumed to mediate the platelet deaggregation. PGE1 also deaggregated these platelets, and a combination of forskolin and PGE1 produced deaggregation greater than the maximum which could be obtained with each agent alone. A greater than additive effect was observed on the platelet cyclic AMP level in the presence of both forskolin and PGE1. No additive effect was observed in the phosphorylation of molecular weight (Mr) 21K polypeptide using forskolin (0.1 mmol/l) and PGE1 (5 mumol/l) suggesting that although cyclic AMP is responsible for the deaggregation process a mechanism other than phosphorylation through cyclic AMP-dependent protein kinase may be responsible for the effect of forskolin on platelet deaggregation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Colforsina
/
Agregação Plaquetária
/
AMP Cíclico
Limite:
Humans
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article