CDK, cyclin-dependent kinase; CDKN1B/p27KIP1, CDKN1B/p27Kinase Inhibitory Protein 1; CDKN2A/p16INK4A, CDKN2A/p16Inhibitor of CDK 4A; CEBP-α, CCAAT/enhancer binding protein alpha; CENP-A, centromere protein A; CIP, Cyclin-Dependent Kinase Inhibitor 1; Cell Cycle; DDR, DNA damage response; ERK, extracellular signal­regulated kinase; GO, Gene Ontology; INK, Inhibitor of CDK; KIP, Kinase Inhibitory Protein; MSCV, murine stem cell virus; OIS, oncogene-induced senescence; PCR, polymerase chain reaction; PDA, pancreatic ductal adenocarcinoma; Pancreatic Ductal Adenocarcinoma; RB, retinoblastoma; RNA-seq, RNA sequencing; SA-ßgal, senescence-associated ß-galactosidase; SKP, S-phase Kinase-associated; Senescence; bHLH; bHLH, basic helix-loop-helix; lfdr, local false discovery rate; mRNA, messenger RNA; shRB, short hairpin RNA directed against RB; shRNA, short hairpin RNA; si-p27, small interfering RNA directed against p27