A stable zinc(II)-mediated base pair in a parallel-stranded DNA duplex.
J Inorg Biochem
; 186: 301-306, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30005358
ABSTRACT
A stable zinc(II)-mediated base pair was formed within a parallel-stranded DNA duplex comprising a GNA (glycol nucleic acid) functionalized nucleoside analog containing the artificial nucleobase 1H-imidazo[4,5-f][1,10]phenanthroline (P). The formation of the metal-mediated base pair was confirmed by UV and CD spectroscopic analyses. In the Zn(II)-mediated homo base pairs of the type P-Zn(II)-P, the metal ion adopts a [2â¯+â¯2] coordination environment. CD spectroscopic data suggest that the chiral metal complex is formed enantiospecifically, likely induced by the helical chirality of the surrounding DNA duplex. The Zn(II)-mediated base pair stabilizes the DNA oligonucleotide duplex by 9⯰C. This stable Zn(II)-mediated base pair within a parallel-stranded duplex extends the scope of site-specific functionalization of nucleic acids by virtue of metal-mediated base pairing.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
DNA
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Modelos Moleculares
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Pareamento de Bases
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Nucleosídeos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article