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A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.
Southam, Hannah M; Smith, Thomas W; Lyon, Rhiannon L; Liao, Chunyan; Trevitt, Clare R; Middlemiss, Laurence A; Cox, Francesca L; Chapman, Jonathan A; El-Khamisy, Sherif F; Hippler, Michael; Williamson, Michael P; Henderson, Peter J F; Poole, Robert K.
Afiliação
  • Southam HM; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
  • Smith TW; Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S3 7HF, UK.
  • Lyon RL; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
  • Liao C; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
  • Trevitt CR; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
  • Middlemiss LA; Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S3 7HF, UK.
  • Cox FL; Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S3 7HF, UK.
  • Chapman JA; Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S3 7HF, UK.
  • El-Khamisy SF; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
  • Hippler M; Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S3 7HF, UK.
  • Williamson MP; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. Electronic address: m.williamson@sheffield.ac.uk.
  • Henderson PJF; School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address: p.j.f.henderson@leeds.ac.uk.
  • Poole RK; Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. Electronic address: r.poole@sheffield.ac.uk.
Redox Biol ; 18: 114-123, 2018 09.
Article em En | MEDLINE | ID: mdl-30007887
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Rutênio / Monóxido de Carbono / Escherichia coli / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Rutênio / Monóxido de Carbono / Escherichia coli / Antibacterianos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article