Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype.

Yu, Tianfu; Wang, XieFeng; Zhi, Tongle; Zhang, Junxia; Wang, Yingyi; Nie, Er; Zhou, Fengqi; You, Yongping; Liu, Ning

Yu, Tianfu; Wang, XieFeng; Zhi, Tongle; Zhang, Junxia; Wang, Yingyi; Nie, Er; Zhou, Fengqi; You, Yongping; Liu, Ning.

Afiliação

Yu T; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Wang X; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Zhi T; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Zhang J; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Wang Y; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Nie E; Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221000, China.
Zhou F; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
You Y; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address: yypl9@njmu.edu.cn.
Liu N; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address: liuning0853@126.com.

Cancer Lett ; 433: 210-220, 2018 10 01.

Article em En | MEDLINE | ID: mdl-30008386

Assuntos

Antineoplásicos Alquilantes/farmacologia; Astrócitos/metabolismo; Neoplasias Encefálicas/patologia; Metilases de Modificação do DNA/genética; Metilases de Modificação do DNA/metabolismo; Enzimas Reparadoras do DNA/genética; Enzimas Reparadoras do DNA/metabolismo; Resistencia a Medicamentos Antineoplásicos/genética; Exossomos/metabolismo; Glioma/patologia; RNA Mensageiro/genética; Temozolomida/farmacologia; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo; Apoptose/genética; Linhagem Celular Tumoral; Humanos; Microambiente Tumoral

Palavras-chave

Astrocyte; Exosomes; Glioma; Microenvironment; Temozolomide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / RNA Mensageiro / Metilases de Modificação do DNA / Astrócitos / Resistencia a Medicamentos Antineoplásicos / Antineoplásicos Alquilantes / Proteínas Supressoras de Tumor / Enzimas Reparadoras do DNA / Exossomos / Temozolomida Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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