Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase.
J Pept Sci
; 24(8-9): e3111, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-30009478
ABSTRACT
Ester linkage (s) is a key chemical connector in organic chemistry, including natural products, peptides, and synthetic polymers. We herein describe a straightforward method for the efficient formation of ester linkage (s) on solid-phase. This method simply involves the use of amide coupling reagents under microwave irradiation. The robustness of this method relies on the use of classical solid-phase coupling reagents, heating by microwave irradiation, and a short time period, which results in high yields and the minimization of racemization.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ésteres
/
Técnicas de Síntese em Fase Sólida
/
Amidas
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Micro-Ondas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article