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In Vitro Antiviral Activity of Cabotegravir against HIV-2.
Smith, Robert A; Wu, Vincent H; Zavala, Christopher G; Raugi, Dana N; Ba, Selly; Seydi, Moussa; Gottlieb, Geoffrey S.
Afiliação
  • Smith RA; Center for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA smithra@u.washington.edu.
  • Wu VH; Center for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
  • Zavala CG; Center for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
  • Raugi DN; Center for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
  • Ba S; Service des Maladies Infectieuses et Tropicales, CHNU de Fann, Dakar, Senegal.
  • Seydi M; Service des Maladies Infectieuses et Tropicales, CHNU de Fann, Dakar, Senegal.
  • Gottlieb GS; Center for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Antimicrob Agents Chemother ; 62(10)2018 10.
Article em En | MEDLINE | ID: mdl-30012774
ABSTRACT
We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC50s) in the low to subnanomolar range; comparable results were obtained for HIV-1 in both assay formats. Our findings suggest that cabotegravir should be evaluated in clinical trials as a potential option for antiretroviral therapy and preexposure prophylaxis in HIV-2-prevalent settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / HIV-2 / Fármacos Anti-HIV Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / HIV-2 / Fármacos Anti-HIV Idioma: En Ano de publicação: 2018 Tipo de documento: Article