Cardiac systolic dysfunction in past illicit users of anabolic androgenic steroids.
Am Heart J
; 203: 49-56, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30015068
ABSTRACT
Background:
Illicit use of anabolic androgenic steroids (AAS) is associated with left ventricle (LV) systolic dysfunction and increased LV mass (LVM), but whether these findings persist in former AAS users has yet to be elucidated. The objective was to assess LV systolic function, LVM and myocardial fibrosis in current and former illicit AAS users compared with non-users.Methods:
Community-based cross-sectional study among men, aged 1850 years, involved in recreational resistance training. We included 37 current and 33 former illicit AAS users, geometric mean (95%CI), 30 (21; 44) months since AAS cessation, and 30 non-users as controls. We assessed myocardial function and structure using advanced echocardiography and cardiac MRI with late-gadolinium enhancement.Results:
Mean (SE) LV global longitudinal strain (GLS) was impaired in former AAS users compared with non-users, −16.7 (0.5) versus −18.2 (0.4) %, Pâ¯<â¯.05. Mean (SE) LV ejection fraction (EF) was decreased, 51 (1) versus 58 (1) %, Pâ¯<â¯.001 and LV GLS impaired, −14.5 (0.4)%, Pâ¯<â¯.001, in current AAS users compared with non-users. Measures of LVM were increased in current AAS users compared with the other two groups, Pâ¯<â¯.001. Plasma total testosterone was independently associated with reduced LVEF (Pâ¯=â¯.049) and increased LVM/body surface area (Pâ¯=â¯.005) in multivariate linear regressions. Focal myocardial fibrosis was not detected in any participants and diffuse myocardial fibrosis, assessed using post-contrast T1-mapping time, did not differ among the three groups.Conclusions:
Past illicit AAS use is associated with impaired LV GLS, suggesting subclinical cardiac systolic dysfunction years after AAS cessation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Função Ventricular Esquerda
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Disfunção Ventricular Esquerda
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Congêneres da Testosterona
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Treinamento Resistido
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Ventrículos do Coração
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Androgênios
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article