Gliotoxin destructs the pulmonary epithelium barrier function by reducing cofilin oligomer formation to promote the dissolution of actin stress fibers.

Zhang, Changjian; Liu, Xiaoyu; Chen, Fangyan; Hu, Yingsong; Li, Zhiqian; Liu, Yanxi; Han, Xuelin; Sun, Yansong; Han, Li

Zhang, Changjian; Liu, Xiaoyu; Chen, Fangyan; Hu, Yingsong; Li, Zhiqian; Liu, Yanxi; Han, Xuelin; Sun, Yansong; Han, Li.

Afiliação

Zhang C; Academy of Military Medical Sciences, Academy of Military Sciences, PLA, Beijing, China; Institute for Disease Control and Prevention of PLA, Beijing, China.
Liu X; Academy of Military Medical Sciences, Academy of Military Sciences, PLA, Beijing, China; Institute for Disease Control and Prevention of PLA, Beijing, China.
Chen F; Institute for Disease Control and Prevention of PLA, Beijing, China.
Hu Y; Institute for Disease Control and Prevention of PLA, Beijing, China.
Li Z; Academy of Military Medical Sciences, Academy of Military Sciences, PLA, Beijing, China; Institute for Disease Control and Prevention of PLA, Beijing, China.
Liu Y; Institute for Disease Control and Prevention of PLA, Beijing, China.
Han X; Institute for Disease Control and Prevention of PLA, Beijing, China.
Sun Y; Academy of Military Medical Sciences, Academy of Military Sciences, PLA, Beijing, China. Electronic address: sunys@qq.com.
Han L; Institute for Disease Control and Prevention of PLA, Beijing, China. Electronic address: hanlicdc@163.com.

Microb Pathog ; 123: 169-176, 2018 Oct.

Article em En | MEDLINE | ID: mdl-30017941

Assuntos

Fatores de Despolimerização de Actina/metabolismo; Actinas/metabolismo; Células Epiteliais/efeitos dos fármacos; Gliotoxina/toxicidade; Pulmão/efeitos dos fármacos; Fibras de Estresse/metabolismo; Células A549/efeitos dos fármacos; Animais; Aspergillus fumigatus/patogenicidade; Linhagem Celular/efeitos dos fármacos; Modelos Animais de Doenças; Células Epiteliais/metabolismo; Humanos; Pulmão/patologia; Camundongos; Camundongos Endogâmicos C57BL; Fosforilação; Solubilidade

Palavras-chave

A. fumigatus; Actin stress fibers; Cofilin oligomer; Gliotoxin; Pneumocyte epithelium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinas / Fibras de Estresse / Células Epiteliais / Fatores de Despolimerização de Actina / Gliotoxina / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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