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Short Communication: Tracking Tregs: Translocation of CD49b/LAG-3+ Type 1 T Regulatory Cells to the Gut-Associated Lymphoid Tissue of HIV+ Patients.
Augustin, Max; Horn, Carola; Koch, Julian; Sandaradura de Silva, Ute; Platten, Martin; Nierhoff, Dirk; Suarez, Isabelle; Chon, Seung-Hun; Rybniker, Jan; Lehmann, Clara.
Afiliação
  • Augustin M; 1 Division of Infectious Diseases, Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Horn C; 2 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
  • Koch J; 3 German Center for Infection Research (DZIF), Bonn-Cologne, Germany.
  • Sandaradura de Silva U; 1 Division of Infectious Diseases, Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Platten M; 2 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
  • Nierhoff D; 3 German Center for Infection Research (DZIF), Bonn-Cologne, Germany.
  • Suarez I; 1 Division of Infectious Diseases, Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Chon SH; 2 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
  • Rybniker J; 1 Division of Infectious Diseases, Department I of Internal Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Lehmann C; 2 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
AIDS Res Hum Retroviruses ; 35(3): 247-250, 2019 03.
Article em En | MEDLINE | ID: mdl-30019612
ABSTRACT
The gastrointestinal mucosa [gut-associated lymphoid tissue (GALT)] represents the largest site of chronic immune activation and HIV replication. Important cellular agents in the immunopathogenesis of an HIV infection are, in particular, CD49b/LAG-3+ type 1 T regulatory cells (Tr1), which secrete large amounts of IL-10 (interleukin-10), and plasmacytoid dendritic cells, the main producers of IFN-α (interferon-alpha). However, the distribution of CD49b/LAG-3+ Tr1 cells along the GALT is unknown.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos CD / Infecções por HIV / Movimento Celular / Linfócitos T Reguladores / Integrina alfa2 / Rastreamento de Células / Mucosa Intestinal / Tecido Linfoide Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos CD / Infecções por HIV / Movimento Celular / Linfócitos T Reguladores / Integrina alfa2 / Rastreamento de Células / Mucosa Intestinal / Tecido Linfoide Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article