Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice.

Tanaka, Shinji; Sugiura, Yuki; Saito, Hisako; Sugahara, Mai; Higashijima, Yoshiki; Yamaguchi, Junna; Inagi, Reiko; Suematsu, Makoto; Nangaku, Masaomi; Tanaka, Tetsuhiro

Tanaka, Shinji; Sugiura, Yuki; Saito, Hisako; Sugahara, Mai; Higashijima, Yoshiki; Yamaguchi, Junna; Inagi, Reiko; Suematsu, Makoto; Nangaku, Masaomi; Tanaka, Tetsuhiro.

Afiliação

Tanaka S; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Sugiura Y; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Saito H; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Sugahara M; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Higashijima Y; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Yamaguchi J; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Inagi R; Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Suematsu M; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Nangaku M; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address: mnangaku-tky@umin.ac.jp.
Tanaka T; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address: tetsu-tky@umin.ac.jp.

Kidney Int ; 94(5): 912-925, 2018 11.

Article em En | MEDLINE | ID: mdl-30021702

Assuntos

Diabetes Mellitus Experimental/tratamento farmacológico; Glucose/metabolismo; Glucosídeos/farmacologia; Rim/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Inibidores do Transportador 2 de Sódio-Glicose/farmacologia; Tiofenos/farmacologia; Animais; Glicemia/análise; Restrição Calórica; Ciclo do Ácido Cítrico/efeitos dos fármacos; Diabetes Mellitus Experimental/metabolismo; Rim/metabolismo; Masculino; Camundongos; Camundongos Obesos

Palavras-chave

albuminuria; diabetes; diabetic nephropathy; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / Estresse Oxidativo / Diabetes Mellitus Experimental / Inibidores do Transportador 2 de Sódio-Glicose / Glucose / Glucosídeos / Rim Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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