Differential effects of tumor promoters on cAMP production: inhibition of receptor-mediated and potentiation of cholera toxin-mediated stimulation.
Biochem Biophys Res Commun
; 133(3): 904-10, 1985 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-3002375
ABSTRACT
Tetradecanoylphorbol-acetate and other tumor promoters inhibit prostaglandin E2 and isoproterenol-induced cAMP accumulation in mouse thymocytes but markedly potentiate cAMP production induced by cholera toxin. Cholera toxin is known to stimulate cAMP production by inducing ADP-ribosylation of the alpha-subunit of a guanine nucleotide-binding regulatory (G) protein, resulting in activation of the catalytic unit of adenylate cyclase. G proteins have been implicated as plasma membrane transducers for a variety of additional signals. It is possible that the growth promoting and co-mitogenic properties of tumor promoters are related to their effects on G proteins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Toxina da Cólera
/
AMP Cíclico
/
Proteínas de Ligação ao GTP
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article