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miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling.
Sendi, Hossein; Mead, Ivy; Wan, Meimei; Mehrab-Mohseni, Marjan; Koch, Kenneth; Atala, Anthony; Bonkovsky, Herbert L; Bishop, Colin E.
Afiliação
  • Sendi H; The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America.
  • Mead I; Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America.
  • Wan M; Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America.
  • Mehrab-Mohseni M; Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America.
  • Koch K; The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America.
  • Atala A; The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America.
  • Bonkovsky HL; Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC, United States of America.
  • Bishop CE; The Laboratory for Liver Diseases and Metabolic Disorders, Section on Gastroenterology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States of America.
PLoS One ; 13(7): e0200847, 2018.
Article em En | MEDLINE | ID: mdl-30024933
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / MicroRNAs / Hepatopatia Gordurosa não Alcoólica / Inflamação / Insulina / Fígado / Necrose Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organoides / MicroRNAs / Hepatopatia Gordurosa não Alcoólica / Inflamação / Insulina / Fígado / Necrose Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article