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Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance.
Grasse, Sabrina; Lienhard, Matthias; Frese, Steffen; Kerick, Martin; Steinbach, Anne; Grimm, Christina; Hussong, Michelle; Rolff, Jana; Becker, Michael; Dreher, Felix; Schirmer, Uwe; Boerno, Stefan; Ramisch, Anna; Leschber, Gunda; Timmermann, Bernd; Grohé, Christian; Lüders, Heike; Vingron, Martin; Fichtner, Iduna; Klein, Sebastian; Odenthal, Margarete; Büttner, Reinhard; Lehrach, Hans; Sültmann, Holger; Herwig, Ralf; Schweiger, Michal R.
Afiliação
  • Grasse S; Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
  • Lienhard M; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Frese S; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Kerick M; ELK Berlin Chest Hospital, Berlin, Germany.
  • Steinbach A; Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Grimm C; Present Address: Department of Cell Biology and Immunology, Institute for Parasitology and Biomedicine, Granada, Spain.
  • Hussong M; Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
  • Rolff J; Department of Biology, Chemistry and Pharmacy, Free University Berlin, Berlin, Germany.
  • Becker M; Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
  • Dreher F; Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
  • Schirmer U; Center for Molecular Medicine Cologne, CMMC, Cologne, Germany.
  • Boerno S; Experimental Pharmacology and Oncology Berlin-Buch GmbH, Berlin, Germany.
  • Ramisch A; Experimental Pharmacology and Oncology Berlin-Buch GmbH, Berlin, Germany.
  • Leschber G; Alacris Theranostics GmbH Berlin, Berlin, Germany.
  • Timmermann B; Cancer Genome Research Group, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Grohé C; Translational Lung Research, Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
  • Lüders H; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Vingron M; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Fichtner I; ELK Berlin Chest Hospital, Berlin, Germany.
  • Klein S; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Odenthal M; ELK Berlin Chest Hospital, Berlin, Germany.
  • Büttner R; ELK Berlin Chest Hospital, Berlin, Germany.
  • Lehrach H; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Sültmann H; Experimental Pharmacology and Oncology Berlin-Buch GmbH, Berlin, Germany.
  • Herwig R; Institute of Pathology, University of Cologne, Cologne, Germany.
  • Schweiger MR; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Weyertal 115b, 50931, Cologne, Germany.
Genome Med ; 10(1): 55, 2018 07 20.
Article em En | MEDLINE | ID: mdl-30029672
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Carboplatina / Carcinoma Pulmonar de Células não Pequenas / Metilação de DNA / Ensaios Antitumorais Modelo de Xenoenxerto / Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Epigenômica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Carboplatina / Carcinoma Pulmonar de Células não Pequenas / Metilação de DNA / Ensaios Antitumorais Modelo de Xenoenxerto / Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Epigenômica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article