How does salt raise blood pressure? A hypothesis.
Hypertension
; 8(1): 83-8, 1986 Jan.
Article
em En
| MEDLINE
| ID: mdl-3002978
ABSTRACT
Existing data in the literature indicate that alpha 2-adrenergic receptor agonists have a profound hypotensive action, that sodium attenuates the affinity of alpha 2-adrenergic receptors for agonists, that the location of these receptors in the central nervous system is mainly at the sites of cardiovascular regulation, and that these sites exert a constant tonic inhibition of sympathetic vasoconstrictor tone. This article proposes the theory that sodium exerts its hypertensive action by decreasing the state of affinity of the alpha 2-adrenergic receptors of the central nervous system for locally occurring agonist neurotransmitters, which results in disinhibition of sympathoinhibitory neurons and leads to the hyperadrenergic state characteristic of salt-induced hypertension.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Cloreto de Sódio
/
Receptores Adrenérgicos alfa
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article