Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.

Du Nguyen, Huy; Okada, Takuya; Kitamura, Shun; Yamaoka, Sakura; Horaguchi, Yamato; Kasanami, Yoshihito; Sekiguchi, Fumiko; Tsubota, Maho; Yoshida, Shigeru; Nishikawa, Hiroyuki; Kawabata, Atsufumi; Toyooka, Naoki

Du Nguyen, Huy; Okada, Takuya; Kitamura, Shun; Yamaoka, Sakura; Horaguchi, Yamato; Kasanami, Yoshihito; Sekiguchi, Fumiko; Tsubota, Maho; Yoshida, Shigeru; Nishikawa, Hiroyuki; Kawabata, Atsufumi; Toyooka, Naoki.

Afiliação

Du Nguyen H; Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan.
Okada T; Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan.
Kitamura S; Faculty of Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
Yamaoka S; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Horaguchi Y; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Kasanami Y; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Sekiguchi F; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Tsubota M; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Yoshida S; Faculty of Science and Engineering, Kindai University, Higashi-Osaka 577-8502, Japan.
Nishikawa H; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Kawabata A; Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
Toyooka N; Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan; Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan. Electronic address: toyooka@eng.u-toyama.ac.jp.

Bioorg Med Chem ; 26(15): 4410-4427, 2018 08 15.

Article em En | MEDLINE | ID: mdl-30031654

Assuntos

Analgésicos/síntese química; Bloqueadores dos Canais de Cálcio/síntese química; Canais de Cálcio Tipo T/química; Desenho de Fármacos; Flavonoides/química; Potenciais de Ação/efeitos dos fármacos; Analgésicos/farmacologia; Analgésicos/uso terapêutico; Animais; Bloqueadores dos Canais de Cálcio/farmacologia; Bloqueadores dos Canais de Cálcio/uso terapêutico; Canais de Cálcio Tipo T/metabolismo; Modelos Animais de Doenças; Flavonoides/farmacologia; Flavonoides/uso terapêutico; Células HEK293; Humanos; Concentração Inibidora 50; Masculino; Camundongos; Neuralgia/tratamento farmacológico; Técnicas de Patch-Clamp; Relação Estrutura-Atividade

Palavras-chave

6-Prenylnaringenin; Flavanone derivative; Mechanical allodynia; Neuropathic pain; T-type calcium channel blocker

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Bloqueadores dos Canais de Cálcio / Desenho de Fármacos / Canais de Cálcio Tipo T / Analgésicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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