Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus.

Nyström, Kristina; Wanrooij, Paulina H; Waldenström, Jesper; Adamek, Ludmila; Brunet, Sofia; Said, Joanna; Nilsson, Staffan; Wind-Rotolo, Megan; Hellstrand, Kristoffer; Norder, Helene; Tang, Ka-Wei; Lagging, Martin

Nyström, Kristina; Wanrooij, Paulina H; Waldenström, Jesper; Adamek, Ludmila; Brunet, Sofia; Said, Joanna; Nilsson, Staffan; Wind-Rotolo, Megan; Hellstrand, Kristoffer; Norder, Helene; Tang, Ka-Wei; Lagging, Martin.

Afiliação

Nyström K; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Wanrooij PH; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
Waldenström J; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Adamek L; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Brunet S; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Said J; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Nilsson S; Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Wind-Rotolo M; Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hellstrand K; Bristol-Myers Squibb, Princeton, New Jersey, USA.
Norder H; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tang KW; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lagging M; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

J Virol ; 92(19)2018 10 01.

Article em En | MEDLINE | ID: mdl-30045981

Assuntos

Antivirais/farmacologia; Hepacivirus/efeitos dos fármacos; Mutagênese; Pirofosfatases/genética; Ribavirina/farmacologia; Antivirais/metabolismo; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Regulação da Expressão Gênica; Guanosina Trifosfato/metabolismo; Hepacivirus/genética; Hepacivirus/crescimento & desenvolvimento; Hepacivirus/metabolismo; Antígenos do Núcleo do Vírus da Hepatite B/genética; Antígenos do Núcleo do Vírus da Hepatite B/metabolismo; Hepatócitos/efeitos dos fármacos; Hepatócitos/enzimologia; Hepatócitos/virologia; Sequenciamento de Nucleotídeos em Larga Escala; Interações Hospedeiro-Patógeno; Humanos; Nucleotídeos/metabolismo; Pirofosfatases/antagonistas & inibidores; Pirofosfatases/metabolismo; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; RNA Viral/genética; RNA Viral/metabolismo; Ribavirina/metabolismo; Transdução de Sinais

Palavras-chave

ITP pyrophosphatase; ITPA; ITPase; hepatitis C virus; inosine triphosphate pyrophosphatase; mutagenesis; ribavirin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pirofosfatases / Ribavirina / Mutagênese / Hepacivirus Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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