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Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss.
Xiong, Jinhu; Cawley, Keisha; Piemontese, Marilina; Fujiwara, Yuko; Zhao, Haibo; Goellner, Joseph J; O'Brien, Charles A.
Afiliação
  • Xiong J; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
  • Cawley K; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
  • Piemontese M; Center for Musculoskeletal Disease Research, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
  • Fujiwara Y; Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
  • Zhao H; Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
  • Goellner JJ; Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
  • O'Brien CA; Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, 72205, AR, USA.
Nat Commun ; 9(1): 2909, 2018 07 25.
Article em En | MEDLINE | ID: mdl-30046091
Receptor activator of NFkB ligand (RANKL) is a TNF-family cytokine required for osteoclast formation, as well as immune cell and mammary gland development. It is produced as a membrane-bound protein that can be shed to form a soluble protein. We created mice harboring a sheddase-resistant form of RANKL, in which soluble RANKL is undetectable in the circulation. Lack of soluble RANKL does not affect bone mass or structure in growing mice but reduces osteoclast number and increases cancellous bone mass in adult mice. Nonetheless, the bone loss caused by estrogen deficiency is unaffected by the lack of soluble RANKL. Lymphocyte number, lymph node development, and mammary gland development are also unaffected by the absence of soluble RANKL. These results demonstrate that the membrane-bound form of RANKL is sufficient for most functions of this protein but that the soluble form does contribute to physiological bone remodeling in adult mice.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Reabsorção Óssea / Ligante RANK Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Reabsorção Óssea / Ligante RANK Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article